Bruno Antonny

Responsabilités


Distinctions

  • 2010 : ERC advanced grant
  • 2009 : CNRS Silver medal
  • 2008 : EMBO member
  • 2001 : EMBO Young Investigator
  • 1998 : CNRS Bronze medal

Biographie

After a PhD on visual transduction with Marc Chabre (1992), Bruno Antonny became interested in membrane biology and performed a post doc with Randy Schekman at UC Berkeley (1999-2000). In 2002, he started a group at the IPMC with the support of the EMBO Young Investigator Programme and an Action Concertée Incitative jeune chercheur.

Among the major achievements of the group:

  1. Membrane geometry is cellular information. The group demonstrated that some proteins sense with great accuracy modest changes in the curvature of the surrounding membranes. This sensitivity contributes to the self-organisation of various cellular processes (e.g. transport vesicle formation).
  2. A lipid exchange market. Various lipid species such as cholesterol are not evenly distributed among cellular membranes and must be actively transported from their site of synthesis to their site of residence. Cellular and biochemical assays demonstrate that the driving force of this transport reaction is the counter-transport and hydrolysis of another lipid, PI(4)P. Thus, this molecule acts as a lipid form of ATP, providing the chemical energy for irreversible lipid transport.
  3. Polyunsaturated lipids as molecular contortionists. Most lipid components of cellular membranes have an intrinsic shape. However, polyunsaturated lipids readily adapt their shape to various membrane stresses including membrane bending. As such, they facilitate reactions that involve fast and acute changes in membrane geometry (e.g. vesicle endocytosis).