Eric Honoré

Responsabilités


Distinctions

  • 2013 : Prize Jean-Paul Binet - Fondation pour la Recherche Médicale (FRM)
  • 2011 : Prize Kidney Foundation
  • 2010 : Prize E. Delcroix VLIZ Flanders Marine Institute
  • 2008 : Prize SGAM - Fondation pour la Recherche Médicale (FRM)
  • 2007 : Prize « La Recherche »

Biographie

Eric Honoré was trained both at the Medical school of Lille and at the University of Calgary (Physics Department), before graduating in 1986. His PhD work concerned the excitation-contraction coupling of cardiac cells. Soon after graduating, he became a lecturer at the University of Science and Technology of Lille, teaching animal physiology and doing research on calcium channels. Then, he moved for a couple of years to the University of Bordeaux for training with the newly discovered patch clamp electrophysiological method. In 1989, he joined the team of Pr. Michel Lazdunski at IPMC to study the molecular physiology of potassium channels.

Next, he was a visiting scientist at the Rockefeller University for two years, where he studied molecular embryology and axonal guidance in the team of Pr. Ali Brivanlou. He started his own group at the IPMC in 2005, focusing on polycystic kidney disease and associated arterial anomalies. His most recent work concerns the role of mechanosensitive ion channels in renovascular physiopathology, with a special focus on Piezo1. The group has demonstrated that opening of Piezo1 contributes to the arterial remodelling of small diameter arteries upon hypertension. The objective of the team is now to investigate the mechanobiology of adipose cells in the context of obesity. It is postulated that a positive mechanical feedback loop acts in the process of adipogenesis. Using a combination of transdisciplinary approaches combining soft matter physics, cell biology, physiology, and clinical studies the group is currently studying how changes in force affect adipose cells. This work will contribute to solve unexplored important questions of integrative physiology and hopefully will yield new valuable perspectives for the fight against obesity and associated metabolic syndrome.