Hélène Marie

Responsabilités


Distinctions

  • 2010 : French ATIP-Avenir Program
  • 2009 : American Alzheimer Association Young Investigator Award
  • 2007 : American NARSAD Young Investigator Award

Biographie

Hélène Marie studied Molecular Biology at the University of Edinburgh, Scotland. She obtained her PhD in Neuroscience in 2000 as a member of the prestigious 4 Year Welcome Trust PhD Program in Neuroscience of the University College London, England. She then spent four years (2001-2005) at Stanford University in the laboratory of Prof. Robert Malenka for her post-doctoral fellowship sponsored by the Wellcome Trust. In 2010, she headed her own group as junior faculty at the European Brain Research Institute in Rome, Italy, an institute directed by the Nobel laureate Rita Levi-Montalcini. In 2010, after 18 years abroad, she came back to France, her home country, and integrated the CNRS. She started her independent team at the IPMC.

By combining strong technical expertise in in vivo viral mediated expression of recombinant proteins, electrophysiology and analysis of rodent behaviour, her current research group studies the molecular and cellular mechanisms of neuronal plasticity at the level of a single neuron and in the context of neuronal circuits. Research focuses mainly on elucidating the physiopathological mechanisms in the context of Alzheimer’s disease and chronic stress. Notably, in 2015, in collaboration with German groups, she published the discovery of a new Alzheimer’s disease-linked peptide with neuronal-modulating properties, which had escaped detection for over 30 years.

The team is actively pursuing the identification of the role of this peptide in the healthy and diseased brain, findings which could significantly alter our view of the physiopathology of Alzheimer’s disease.