Michel Lazdunski

Responsabilités


Distinctions

  • 2013 : Prize Paul Ehrlich
  • 2012 : Prize Galien France
  • 2003 : “Grand Prix” - Fondation pour la Recherche Médicale (FRM)
  • 2000 : CNRS Gold medal
  • 1983 : Prize Charles Leopold Mayer (“Grand Prix”) - French Academy of Sciences

Biographie

 

Worldwide specialist in ion channels, Michel Lazdunski is the author, with his team, of more than 600 articles published in international literature and internationally recognized work on both the fundamental level (study of the structure, function and regulation of canals, discovering new channels) and in terms of their pharmacological and pathophysiological applications, ranging from understanding the antihypertensive mechanisms, antidiabetic or gaseous anesthetics mechanisms of pain perception, cystic fibrosis, cardiac arrhythmias, seizures and epilepsy, stroke, retinal and spinal ischemia, neuroprotection and depression.

Michel Lazdunski started as an engineer in chemical engineering; he then got a PhD in Physical Chemistry and a Doctorat ès Sciences in Biochemistry. His first research activities in biological sciences were in enzymology. He then gradually moved to ion transport systems and more specifically to the molecular analysis of ion channels at a time when it was not even known that these channels were proteins. He first developed tools (toxins in particular) to analyze the properties of Nav channels, then worked with Cav channels, all sorts of K+ channels  and CFTR, epithelial Na+ channels, acid-sensitive ion channels, peptide-gated ion channels, always linking molecular studies with developmental biology, pharmacology, physiology and physiopathology. He has a particular interest for the implications of ionic channels in epilepsy, ischemia and neuroprotection, pain and behavioural disorders. For more than 30 years he has developed toxins and more specifically peptide toxins for all sorts of ion channels.

He has been the Founder and Director of the Centre de Biochimie (CNRS) in Nice in 1973 and IPMC in Sophia Antipolis in 1989.

Michel Lazdunski is a member of several Academies among which the French Academy of Sciences and the Academia Europae.