Dr. Mohamed MEHIRI

Mohamed is head of the Marine Natural Products team at the Institute of Chemistry of Nice (ICN). He focuses on the characterization and production of small natural molecules identified as secondary metabolites of marine invertebrates and microorganisms used in ecophysiology, biology, pharmacology or cosmetics

Responsibilities

chercheur (Maitre de Conférence (MC, HDR))
Institut de Chimie de Nice (ICN)
Université Nice Sophia Antipolis (UNS)

Distinctions

  • CNRS
  • INSERM
  • Université de Nice

Biography

The Marine Natural Products theme focuses on the different aspects of the chemistry of natural substances with, mainly, the characterization and production of small natural molecules identified as secondary metabolites of marine invertebrates and microorganisms. Many marine organisms, particularly invertebrates that are often associated with symbiotic microorganisms, represent an under-explored source of new natural products that are responsible for a variety of biological activities in situ (antibiotic, antifungal, anti-fouling, etc.). same as valuation. These secondary metabolites frequently have original structures, often bioactive, different from those of the terrestrial environment. These are tools used in ecophysiology (toxins), biology (taxonomy), pharmacology or cosmetics. In the search for new therapeutic agents from the sea, about twenty molecules are at various stages of the clinical phase and five drugs of marine origin are currently marketed. The latest anti-cancer drugs are Trabectedine® (or Yondelis, PharmaMar ™), isolated from the colonial ascidian Ecteinascidia turbinata, and Halaven® (or Eribuline mesylate, EISA ™), a synthetic halichondrin B analog isolated from the sponge. marine Halichondria okadai, marketed in 2007 and 2010.

Research and activities
Research fields
Isolation of natural substances from marine organisms
Synthesis of marine metabolites
Medicinal chemistry
Teaching

Course on total synthesis, as part of the preparation for the aggregation of physical sciences, chemistry option
Course on molecular orbitals and organic chemistry for the preparation for the aggregation of physical sciences, option chemistry

Coordination chemistry labs in Master, Pharmaceutical lab in Master FOQUAL, Physical chemistry lab & Organic Chemistry in bachelor