Professional Master Biobanks and Complex Data Management
- Composantes : UFR Sciences
- Domaine : Sciences de la Vie et de la Santé
- Mention : Management des Biobanques
- Spécialité : Biobanks and Complex Data Management
- Année de sortie : Bac+5
- Effectifs : 15+
- Lieux de formations : Nice (Valrose, Hôpital Pasteur, IRCAN) et Valbonne Sophia-Antipolis (Institut Sophia Agrobiotech, Institut de Pharmacologie Moléculaire et Cellulaire)
A Biobank is a biological materials repository that collects, processes, stores, and distributes biospecimens to support scientific investigation.
Biobanks can contain or manage specimens from animals, including humans, and many other living organisms. Vertebrates, invertebrates, arthropods, and other life-forms are just a few of the many classes of living organisms which can be studied by preserving and storing samples taken.
The purpose of a Biobank is to maintain biological specimens, and associated information, for future use in research. The Biobank assures the quality, and manages the accessibility and distribution/disposition of the biospecimens in its collection. The four main operations of a Biobank are; (i) collection (ii) processing, (iii) storage or inventory, and (iv) distribution of biological specimens.
The hype in biobanking and the boost of biobanks in the last 2 decades has led to the development of a huge number of biobanks around the globe. The number of human biobanks has especially grown, culminating in a total amount of about 200 million specimens currently stored in these. These human biological specimens include tissues (fixed and embedded in paraffin or stored at very low temperatures as cryo samples), bodily fluids (blood and derivatives, urine, saliva, but also liquor, follicular fluid, seminal fluid, etc.) and isolated biological structures (DNA, RNA, proteins, primary cells). Each and every biobank needs to connect samples to their associated data. In human biobanks these comprise mostly clinical data; however, data may also be derived from experimental data (e.g. data from omics technologies) or data related to demographic, environmental and social parameters of the donors. Of course, all this data needs to be saved and connected to the samples in a way ensuring protection of any personal data of the donors.
Lack of Definitions
Like any hype, due to its fast development biobanking has generated quite a lack of definitions that can be related to the pool of “How” questions related to this. To name a few:
- How is the collection strategy of a biobank defined?
- How is sample integrity preserved during sample collection?
- How is sample quality maintained during sample storage?
- How is the direct link between sample and data secured?
- How can the highest quality of data and samples be achieved and conserved?
- How is the privacy of donors protected?
- How can the samples be made available for academic and industrial research partners worldwide?
- How can scientists find the quality and quantity of samples needed for their studies?
- How can sustainability of biobanks, especially academic biobanks be assured?
Although there is the need to define a collection strategy, there is no requirement to standardize collection strategies in different biobanks or the amount of samples stored in a single biobank. At the same time, a single aliquot in a freezer should not be termed a biobank per definition as is true for specific countries.
Higher Level of Communication and Education
The further development of the field of biobanking is crucially dependent on a deep analysis of problems and challenges. High levels of harmonization and quality standards need to be set up to guarantee data and sample qualities in biobanks that match the needs of the new developing assays, especially the – omics technologies. This can only be achieved by communication on a very high level. International biobank networks, organizations and societies [including “Infrastructure Biobanques” (http://www.biobanques.eu/fr/), the European, Middle Eastern and African Society for Biopreservation and Biobanking – ESBB (http://www.esbb.org/), International Society for Biological and Environmental Repositories – ISBER (http://www.isber.org/), the Biobanking and Biomolecular Resources Research Infrastructure –BBMRI-ERIC (http://www.bbmri-eric.eu/)], as well as superregional biobanks will be heavily involved in setting up the framework of definitions and standards for the harmonization of biobanking activities. In this framework, defining standards of SOPs (standard operation procedures) for sample and data handling, securing personal rights of donors in a networking world and certifying quality management procedures especially in biobanks are essential steps towards harmonization.
The integration of industrial research and partners into public biobank activities presents an important aspect to achieve an innovative and sustainable benefit for both, private partners and biobanks, to finally bring medical research into new horizons and advance health care for the population in general.
Therefore, biobanks have become a real scientific battlefield, which is proven by increasing numbers of publications on biobanking science and procedures in the last decade. There is an increasing need in the necessity of experts in biobanking in the future. Thus, the high demand for educating experts in the field of biobanking creates the need for a well-structured postgraduate training and education system.
Currently, there are only few opportunities around the world for postgraduate master education in Biobanking with academic courses teaching all technical, scientific and legal/ethical aspects of human and environmental biobanking.
The main objective of this Professional Master is to acquire knowledge, experience, and practical skills that will qualify graduates of the Master for working in the multidisciplinary field of biobanking (humans, animals, plants, and other living organisms) and complex data management.
The Master will provide the following skills and knowledge to students:
- Organization and implementation of biobanks at the national and international levels
- Quality management and risk management of biobanks
- Infrastructure of a biobank, budgeting and biobank sustainability or 'Biobankonomic'
- Sample management and ethical, legal, and societal aspects of biobanking
- Management of complex data associated to biological samples (including biostatistics, epidemiology, mathematical modelling and machine learning)
- European and International biobanking networks
- Professional development and Marketing
Level Bac + 3 degree validated in Life Sciences. The Master welcomes applications from candidates of all nationalities who are fluent in English.
The registration is a 2 phase process: a) a first selection is made based on the evaluation of your application and supporting documents, and b) the pre-selected candidates will then be invited for a face-to-face or Skype interview. Apply online at: http://unice.fr/formation/inscriptions
4. MASTER’S PROGRAM
The training takes place over 2 years (4 semesters) and delivers 120 ECTS credits.
A large place is given to internships in France and abroad: 12 months on the two years of training.
Teaching language: French (50%) and English (50%)
First year (M1)
TM1. The world of Biobanks
TM2. Quality & Biobanks
TM3. Ethics, legislation & social issues
TM4. Hygiene and safety
TM5. Project management
Second year (M2)
TM1. Economic model
TM2. Complex data management
TM3. International networks
TM4. Communication & Marketing
TM5. Manage your future career
Hands-On Seminars (students oral session, SOS)
Students will dedicate themselves to group-based studies. They will be asked to defend their analysis of a concrete, current issue raised by a biobank. The group recommendations will be presented in front of faculty members.
Internship market workshops
Internship market workshops aim to better prepare students for their internship search and cover topics like CV presentation, assessment centers and handling interviews.
Students must write a master's thesis to graduate from this program. It represents an important component of the Master’s learning experience. The objective of the thesis is to explore cutting-edge research implementation in daily practice within a highly competitive biobanking environment.
5. JOB OPPORTUNITIES
"Biobanks and Complex Data Management" Professional Master prepares graduates for a number of high-level positions in biobanking with a strong emphasis on industrial, technological and international environment. Graduates of the program may qualify for these positions:
- Biobank Manager/Administrator
- Biobank quality Manager
- Data Manager
- Scientific Adviser to public and private sector clients
- Product Manager
- Regulatory Specialist
- Technological Specialist
- Logistics Specialist
- Logistics Manager/Administrator
- Logistics Analyst
Jobs opportunities :
- Academia laboratories
- Hospital laboratories and biobanks
- Private companies (pharmaceutical and biotechnology industry, diagnostic companies)
- Biodiversity conservatories
- National and international non-profit organizations
6. INSTITUTIONAL PARTNERS
- Université Côte d'Azur; http://univ-cotedazur.fr/english
- University Hospital Federation « OncoAge »; www.oncoage.org
- Infrastructure Biobanques; www.biobanques.eu
- Centre Hospitalier Universitaire de Nice ; www.chu-nice.fr; www.biobank06.com
- Centre Antoine Lacassagne, Nice; www.hopital-centre-antoine-lacassagne.fr
- Institut national de la recherche agronomique (INRA) : www.inra.fr
- INRIA ; http://www.inria.fr/
- Cancéropôle PACA ; http://canceropole-paca.com/
Contact details :
Director: Professor Paul Hofman
Biobanque Hôpital Pasteur
30 VOIE ROMAINE CS 51069
06001 Nice Cedex 1, France
Deputy Directors: Dr Nicole Arrighi and Dr Marius Ilié