MODELIFE Event

COLLOQUIUM

Présentation

Colloquium MODELIFE

24 Avril 2019

Laboratoire J.-A. Dieudonné

Parc Valrose


David RAND 

Mathematics Institute & Zeeman Institute for Systems Biology and Infectious Epidemiology Research 
University of Warwick, UK. 
Stacks Image 681

Multiplexing information flow through dynamic signalling systems 

Recent work has suggested that in dynamic cellular signalling systems like NF-κB and ERK the mutual information between input and response is relatively low and less than 2 bits. On the other hand, it is generally believed that the NF-κB system uses the information from a large number of input signals to regulate gene transcription of more than 500 genes in a highly versatile way. It regulates cell fate and inflammatory signalling in response to diverse stimuli, including viral and bacterial pathogens, free radicals, cytokines and growth factors. I will propose a resolution of this potential paradox by studying signal multiplexing and its relation to decision-making. I will describe some experiments that support this idea, discuss the underlying mathematical approach, explain when systems can and can't multiplex, and model some aspects of the multiplexing seen in NF-κB. As part of this I will introduce a new mathematical method for the analysis and simulation of large stochastic non-linear oscillating systems. This allows an analytic analysis of the stochastic relationship between input and response and shows that for tightly-coupled systems like those based on current models for signalling systems, clocks, and the cell cycle this relationship is highly constrained and non-generic. 

Programme

 
14:00 : Welcome 

14:15  : F. DELAUNAY  - iBV, Nice  - Introduction 

14:30 : D. RAND  - U. of Warwick, UK  - Multiplexing information flow through dynamic signalling systems 

15:30 : Coffee 


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Accès

Adresse

06100, Nice, Avenue de Valrose,

Laboratoire J.-A. Dieudonné

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