19 -21 May 2019
Nice, France
Faculté des Sciences Théâtre du Grand Château 

Key Speakers
Prof. Nick Hastie (Edinburgh, UK)
Prof. Haruo Sugiyama (Japan)

Sessions
WT1 and Embryonic Development
WT1 and Cancer – basic science
Molecular biology of WT1
WT1 and clinical cancer trials
WT1 in tissue repair and homeostasis

Organising Committee
Kay-D Wagner
Nicole Wagner
Andreas Schedl
Marie-Christine Chaboissier
Isabelle Gillot

Registration deadline : 1st February and abstract submission : 31th of March 2019

Download WT1 biology poster

For more information, please contact WT1-2019@unice.fr



SUNDAY 19th MAY

16.00-18.00 Guided Tour of the old city of Nice
18.00 Welcome drink

MONDAY 20th MAY

8.00 Welcome and registration
8.45 Opening remarks
9.00 WT1 and EMBRYONIC DEVELOPMENT

Chairs: Christoph Englert and Andreas Schedl

  • 9.00 Ramon Munoz-Chapuli: Lineage tracing of WT1-expressing cells in heart development
  • 9.20 Marie-Christine ChaboissierWt1 at the crossroad of sex determination
  • 9.40 Bettina Wilm: Analysing the role of Wt1 in the formation of peritoneal and intestinal vasculature
  • 10.00 Danny Schnerwitzki: The exploration of a terra incognita – Wt1 in the hindbrain
10.20-10.45 Coffee Break and Poster Session
10.45

WT1 and CANCER - BASIC SCIENCE
Chairs: Michael Ladomery and Viggo Van Tendeloo

  • 10.45 Nicole Wagner: In search of pharmacological inhibitors of WT1 as potential cancer treatment
  • 11.05 Karamjit Singh Dolt: Secondary iPSC reprogramming to study the role of Wt1
  • 11.25 Kay-D. Wagner: Altered VEGF Splicing Isoform Balance in Tumor Endothelium Involves Activation of Splicing Factors Srpk1 and Srsf1 by the Wilms’ Tumor Suppressor Wt1
  • 11.45 Soyoko Morimoto: Establishment of a novel platform cell line for efficient and precise evaluation of T cell receptor functional avidity and its application
  • 12.05   Renata Stripecke: Monocytes reprogrammed into dendritic cells with a lentiviral vector for priming the de novo development of T and B cell responses against WT1 in AML patients.
12.25 -14.00 Lunch
14.00 MOLECULAR BIOLOGY of WT1

Chairs: Peter Hohenstein and Kay Wagner

  • 14.00 Stefan Roberts: Mechanisms of transcriptional regulation by WT1-BASP1.
  • 14.20 Abdelkader Essafi: WT1 and the intermediate stages of EMT/MET
  • 14.40 Katharina Krueger: Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression mediated by HIF-independent chromatin looping
  • 15.00 Kathryn F. Medler: The WT1-BASP1 complex is required to maintain the differentiated state of taste receptor cells

15.20-16.00 Coffee Break and Poster Session

16.00 -17.00 Keynote presentation:

Chairs: Andreas Schedl and Nicole Wagner

  • Prof. Nick Hastie: From Wilms’ tumour to mechanisms of development, homeostasis and repair
18.00 Guided City center visit
19.30 Dinner at Saint Paul Restaurant (see map)

TUESDAY 21th May

9.00

WT1 and CLINICAL CANCER TRIALS –Part 1
Keynote presentation:
Chairs: Zwi Bernemann and Nicole Wagner

  • 9.00 Prof. Haruo Sugiyama: Cancer immunotherapy targeting WT1 protein
  • 10.00 David Scheinberg: Clinical Trials of a WT1 Multivalent Peptide Vaccine
10.40-11.15 - Coffee Break and Poster session 
11.15

WT1 and CLINICAL CANCER TRIALS –Part 2
Chairs: Haruo Sugiyama and David Scheinberg

  • 11.15 Viggo Van Tendeloo: Preclinical evaluation of Wilms’ Tumor-1 targeted interleukin-15 dendritic cells
  • 11.35 Fumihiro Fujiki: Comparison of WT1-specific T cell responses in recurrent glioma patients received CTL + Helper peptide vaccine vs CTL peptide vaccine alone.
  • 11.55 Zwi Berneman: Therapeutic vaccination of cancer patients with Wilms’ tumor 1 (WT1) mRNA-electroporated dendritic cells (DC): Correlation of clinical effects and overall survival with T-cell response
12.15 – 13.30 Lunch break
13.30 

WT1 in TISSUE REPAIR and HOMEOSTASIS
Chairs: Abdelkader Essafi and Stefan Roberts

  • 13.30 Michael Boyes: Analysing the role of Wt1 in mesothelial cells.
  • 13:50 Thomas Wilm: Proof that mesothelial cells directly contribute to peritoneal scars in vivo.
  • 14.10 Ines Marques: Expression of wilm’s tumor genes in zebrafish cardiomyocytes during development causes atrial hyperplasia and fibrosis
14.30 Closing remarks

Venue

Attention: The International conference on WT1 biology will coincide with the 72nd Cannes Film Festival and we expect flights and hotels to sell out. We therefore advice participants to make travel arrangements (flights/hotels) as early as possible!

Théâtre du Parc Valrose 

Université Nice Sophia Antipolis
28 avenue Valrose
06108 Nice, France

You can join Nice by plane, railway, or car. The emblematic Parc Valrose is located in 28 Avenue Valrose, in the center of Nice. Please note that the Parc Valrose is not located in Nice Sophia Antipolis.
Bus lines: 23/24/37 — Tram line: 1
plan1.jpg

Valrose

Hôtel Vendome 

26, rue Pastorelli
06000 Nice

Hotel's Website


Hotel Villa Rose 

43, Avenue Bellevue
06100 Nice

Hotel's Website


Hotel Villa Saint Hubert 

26, rue Michel-Ange
06100 Nice

Hotel's Website


Hotel Monsigny 

17, avenue Malaussena
06000 Nice

Hotel's Website

Kay-D Wagner
Nicole Wagner
Andreas Schedl
Marie-Christine Chaboissier
Isabelle Gillot

Université Côte d'Azur
CNRS
logoLigue.png
logoInserm.png
IBV.jpg
nice.png