Chimie verte - chimie durable

Chimie verte - chimie durable

Responsable: Sylvain ANTONIOTTI (Directeur de Recherche CNRS)

Main research activities

■Catalytic methodologies in organic synthesis

■Green and sustainable chemistry

■Nanocatalysis

■Supported metal catalysis (Bi, Fe, Cu, In, Ga)

■Biocatalysis (hydrolases, peroxidases, monooxygenases)

■Essential oils modification

■Flavours and fragrances

https://www.facebook.com/chimievertechimiedurable

********************** NEWS **********************

May 7th: Sylvain gives a lecture on sustainable chemistry in the manufacture of fragrance ingredients at the annual meeting of the chemistry doctoral school of Marseille.

April 26th: Sylvain gives a lecture on heterogeneous catalysis, multicatalysis and flow chemistry at the annual regional meeting of the French chemical society held in Nice.

Mars 28th: Master perfumer Christophe Laudamiel will in the lab for 2 days to perform GC-O on odorant natural complex substances in order to identify new potent odorant molecules.

Mars 14th: Today we hold our first joint Symposium with the Monell Chemical Senses Center.

March 5th: Grand opening of the application lab of the CCISO at Grasse Biotech in the presence of our VP for research Jeanick Brisswalter and the Mayor of Grasse Jérome Viaud !

January 29th: First day of Manon in the lab for her Master internship to work on zeolite doped with copper and its use in synthetic methods development. 

January 14-15th: Sylvain to participate in a Convergence CNRS meeting to try to shape the future of the research in the synthesis of complex molecules in France.

January 11th: New year celebration an party at Université Cote d'Azur ! Dare to create will be our motto for 2019.

January 4th: First day for Jihene at ERINI lab for her Master internship to work on the analysis of leachables and extractables in essential oils from plastic containers.

2019

December 4th: Today the group welcomes Laure Gilles to start a PhD thesis on the discovery and total synthesis of odorant molecules by innovative technologies and approaches.

November 22nd: Last paper from Hélène and André on an enzyme-based approach for the removal of atranols from oakmoss absolute published in open access journal Cosmetics.

November 14th: Heading to Berlin to meet Master perfumer Christophe Laudamiel to smell some fruity esters prepared following a procedure from Fehling published in 1857 and learn more about his unique approach of fragrance creativity. 

October 12th: We have the visit of Prof. Jaroslav Polanski to give a conference and start a new collaboration on solid catalyst.

October 6th: Sylvain gives a conference to a broad audience on sustainable chemistry at the occasion of the science festival.

October 1st: Today we welcome Marissa and Mathilde in the group to start their PhD theses on complex natural substances chemistry.

September 28th: Today we have the visit of Dr. Bob Margolskee from Monell Chemical Senses Center to give a conference and sign a partnership with Université Cote d'Azur.

September 25th: Sylvain gives a conference at perfume company Jean Niel in Grasse. 

July 12th: PhD cofunding for a project on innovative fragrance ingredients in collaboration with IFF-LMR Naturals.

July 10th: Technical note with J.-G. Boiteau on nucleophilic organometallic reagents is now online.

July 4th: Not only the Independence day of our American friends and fellows but the closing meeting of Essenzyme project cofunded by Région PACA.

June 29th: This was the last day of Gaia in the group, good luck for your future career in analytical chemistry !

May 29th: Sylvain to give an invited seminar at Katowice University (Poland) and start a collaboration with Prof. Jarek Polanski.

May 15th: Paper submitted to the proceedings of UCA Complex Days starring Nelli, Alexandra and Pascal ! 

April 19th: Succesful PhD thesis defense of Hélène Bouges !

March 29th: Sylvain to give an invited seminar at Montpellier Chimie Balard.

March 15th: Paper from Pascal in Eur. J. Org. Chem appeared on line with a nice cover picture from Ella Maru studio.

March 12th: European patent application submitted for the results of Hélène in the manufacture of atranol-free oak moss absolute by enzymatic treatment.

March 7th: Sylvain appointed editorial board member of Molecules in the Green Chemistry section

February 8th: Plenary conference of Sylvain at the Regional meeting of the French Chemical Society in La Rochelle.

January 3rd: Bin Li join the group for a 6-month Master of Science training at ERINI to work on contamination of essential oils by migration of substances from plastic containers.

January 3rd: Gaia Cesarone join the group for a 6-month internship as an Erasmus+ student to work on Perfumalism project.

2018

December 12th: succesful PhD thesis of Pascal D. Giorgi who will be flying soon to join Prof. Kenji Hara's lab at Tokyo University of Technology.

October 1st : Sylvain is promoted Research Director at CNRS.

September 13th : Book chapter of Pascal accepted.

July 10th : Sylvain appointed board member of the cluster PASS.

July 7th : Last day of Alexandra in the group. Thank you for your contribution to the topic of multicatalytic reactions.

June 27th : Last paper from a collaboration with our friend V. Dalla on tin triflimide catalysis in N-acyliminium ion chemistry accepted in Eur. J. Org. Chem.

April 25th : Funding from IDEX for the interdisciplinary project Dylight gathering physicists, biologists and chemists to develop light-controlled neurons.

April 7th : 1st Masterclass NiceFlow !

March 1st: Sylvain is appointed Director of the Centre for Creativity and Innovation in Sciences of Odorants, a novel IDEX innovation platform.

February 8th : Full paper from Pascal and Nelli just accepted at ChemCatChem !

January 24th : First paper of Hélène just accepted in Flavour Fragr. J.

January 10th : first day of Alexandra in the group for her Master internship.

2017

December 27th : Paper on vetiver enzymatic acylation accepted at ChemPlusChem and highlighted in Wiley Hot topics : biocatalysis.

November 18th : Sylvain elected President of the Scientific board of ERINI platform.

September 30th : Pascal’s paper still in press but already highlighted in Wiley Hot topics : Sustainable chemisty and selected for the cover of ChemCatChem first issue of 2017.

September 7th : first paper of Pascal on one-pot bicatalytic multistep reactions just accepted in ChemCatChem.

July 14th : 1st paper of Nelli on Hosomi-Sakurai reactions in batch and in flow catalysed by bismuth-doped clays accepted in ChemistrySelect.

July 7th : Back from BOS2016 in Riga with excellent lectures from Brian Stoltz and Ryan Schenvi among others ...

June 25th : today was the last day of Nelli in the group ... Thank you very much for your contribution and in particular for our first results in flow !!

June 20th : the group welcome André Monchot, who joined the group as analytical chemist to work on the project Oakmoss.

April 25th : back from JFIC2016 where Nelli gave a talk on her results on a Bi-MMT-catalysed Hosomi-Sakurai reaction both in batch and flow.

April 19th : Oakmoss project, aimed at providing sustainable enzyme-based processes for the manufacture of atranol-free all-natural oakmoss extracts, get the financial support of SATT sud-est.

February 3rd : RSC Advances full paper on hydroalkoxylation from our collaborative work with Drs C. Aymonier (ICMCB) and M. Pucheault (ISM Bordeaux) accepted.

February 2nd : Chem. Eur. J paper from our collaborative work with Prof. V. Dalla (U. Le Havre) accepted.

2016

December 22nd : Hélène is awarded a Giract 1st year PhD Flavor Research Student bursary.

December 7th : MUSICS project approved by cluster PASS.

November 23rd : Sylvain receives the CNRS Excellence in research and doctoral advisory award.

September 25th : back from Digne at the 34th International symposium on essential oils and extracts where Sylvain gave a talk on enzymatic essential oils modification.

September 15th : Installation of a complete Vapourtec flow chemistry system in the lab.

August : Sylvain continues its 2015 USA summer tour with a conference at City College of New York, a talk at ACS meeting in Boston and a conference at University of Missoula (MT).

July 1st : The group welcome Dr Nelli Elizarov, freshly graduated from Potsdam University who is joining the group as a post-doctoral fellow funded by the French embassy in Germany.

June 8th : today was the last day of Irene in the group after 2.5 years with us :’-( We wish her the very best for her career.

May 29th : European patent application submitted for our biotechnological process for the preparation of vetiveryl esters.

May 4th : Sylvain is back from Madrid where he gave the opening lecture of the EPTES Flavors & Fermentation workshop.

April 22nd : the whole group attended the SCF regional meeting and presented two posters from Irene and Pascal.

January : the group welcome Thierry Auer for a 6-months MSc training to work on the synthesis of novel photoisomerisable molecules (collab. G. Sandoz iBV).

2015

December 5th : Green Chemistry paper on hydroalkoxylation catalysed by metal cations supported on montmorillonite appears on line. Link.

December : the group welcome Hélène Bouges who is joining as a PhD student on the Essenzyme project.

November 18th : Essenzyme project get a financial support from the Scientific board of the University Nice Sophia Antipolis.

November 6th : Tetrahedron paper on tandem thioacylation/cyclisation of 1,6-enynes in the presence of Au-Pd NPs appears on-line. Lien.

October 25th : Sylvain is back from Anglet where he gave the Introducing lecture at the Screen autumn school on green and sustainable chemistry.

October : Review article on bimetallic nanoparticles in catalysis published in ChemCatChem (link)

October : the group welcome Pascal Giorgi who is joining as a PhD student to work on the development of new tandem multicatalytic reactions.

September 8th : kick-off of the project NVA (natural vetiveryl acetate) with the financial support of SATT-sud est.

July 11th : Essenzyme project get the financial support of the Conseil Regional PACA for three years.

July 1st : a review article on the enzymatic modification of essential oils published on-line in open access. Link.

May 5th : Back from Torino (IT) where Irene gave a talk at the GIFC7.

March 18th : PhD thesis position available for excellent candidates (http://www.unice.fr/icn-s/spip.php?...).

2014

August 15th : Jade’s paper accepted in Chemisty & Biodiversity !

June 28th : end of the MS internship of Jade and Justine and the undergraduate training of Edwige. Good luck and thanks a lot for your contribution !!

May 27th : Sylvain is back from ISGC2 where he gave a talk and attended many inspiring lectures.

April 11th : Irene and Justine won the RSC New Journal of Chemistry best poster award at the regional meeting of the French Chemical Society ! Congratulations !

2013

Group leader : Dr Sylvain Antoniotti

  • Mathilde Lecourt, PhD student, biocatalysis, IFF-LMR / Région PACA funding.
  • Marissa Pierson, PhD student, analysis of natural complex substances, new approaches for the detection of adulteration of essentials, ERINI platform, Industrial funding.
  • Laure Gilles, PhD student, synthesis and discovery of odorants, Industrial funding.
  • Jihen Ayari, Master student (Univ. Nice), ERINI platform, contamination of essential oils used in perfumery.
  • Manon Pujol, Master student (Univ. Strasbourg), heterogenous catalysis and flow chemistry.
group2019xsmall
De gauche à droite : Fabrizio Claire (Innovation) Frédéric (Campus APC) Mathilde Marissa Manon Laure and Jihene (Recherche).

bbq group
Pascal, Irene, Thierry, Hélène, Nelli, Sylvain (August 2015).

Sylvain, Thierry, Irene, Hélène, Pascal (feb 2015)

Jade, Irene, Sylvain, Justine, Tiên (jan 2013). 


Anciens/Alumni (-> and their next position)

Géraldine Jouan, Master 2 UNS, 2005-2006

Reine-Marie Dia, Master 2 UNS, 2006-2007 (-> PhD student)

Julien Blanc, L3 UNS, 2007 (-> chemist, Ortec)

Alice Delorme, Master 2 ENSCCF, 2007-2008 (-> Cosmetic industry)

Dr Rim Belaqziz, Thèse U. Marrakech, 2008-2010 (-> teacher, Marrocco)

Dr Karen Damian, post-doc UNS (ANR), 2008 (-> sales rep., Italy)

Dr Christine Pintaric, post-doc UNS (ANR), 2009 (-> ARC)

Elsa Raynaud, L3 (U. Paris Sud), 2009 (-> Chemist, Firmenich CH)

Marine Belmonte, M1 UNS, 2009 (-> perfumer)

Charfeddine Bouhlel, Master 2 UNS, 2009-2010 (-> chemist R&D, Virbac)

Gwenn’Ann Dolhem, M1 Polytech Nice, 2010 (-> PI engineer)

Ludovic Marciasini, M1 UNS, 2011 (-> PhD student)

Dr Vito Vece, Thèse U. Nice Sophia Antipolis (ANR), 2011 (-> research assistant, U. Milano IT)

Dr Julien Godeau, Thèse U. Nice Sophia Antipolis (ANR), 2012 (-> post-doc IRCOF)

Dr Thi Kieu Tiên Do, Thèse U. Nice Sophia Antipolis (Botanicert), 2011-2014 (-> Scientist, Kamag CH)

Khadija Ben Hadj Hassen, Master 2 UNS, 2011-2012

Jade Ramilijaona, Master 2 UNS, 2012-2013 (-> Quality control, Naturex)

Justine Giauffret, Master 2 UNS, 2012-2013 (-> Chemist at Asepta)

Edwige Craste, L3 UNS, 2013 (—> Master student FOQUAL)

Morgane Vanpeene, ENSCCF training, 2013 (->R&D engineer at Saint-Gobain)

Dr Irene Notar Francesco, post-doc, 2012-2015 (-> Scientist, Fragonard)

Thierry Auer, Master 2 UNS, 2014-2015 (-> Forensic chemist, French police)

Dr Nelli Elizarov, post-doc, 2015-2016 (-> Post-doc group of Dr Azoulay)

André Monchot, Ingénieur d’étude, 2016 (-> Engineer at Altran)

Alexandra Yeromina, Master 2 UNS, 2017 (-> PhD thesis Cardiff U.)

Dr Pascal D. Giorgi, Thèse Université Cote d’Azur, 2014-2017 (-> Post-doc group of Prof. Kenji Hara, Tokyo University of Technology, Japan)

Dr Hélène Bouges, Thèse Université Cote d'Azur, 2014-2018 (-> CDI Chemical engineer Centre Antoine Lacassagne, Nice, France)

Bin Li, Master 2 UNS, ERINI

Nanocausys project 2012-2016

Funded by ANR CD2I

The project Nanocausys (Nanostructured catalysts in unconventional systems), involving 5 French academic laboratories (ICN, ISM, ICMCB, ICCF, LOF) and the European chemical company Solvay (via E2P2L), is funded by ANR program “Sustainable Chemistry, Industry, Innovation”. This project is aimed at demonstrating the feasibility of heterogeneous catalysis in continuous reactors for industrial applications. We have chosen an integrated approach taking into account matrix, catalysts and reactor designs through the combined expertise of scientists from material science, catalysis and biocatalysis, microfluidics and reactor engineering. Nanostructured catalysts will be used in 3 categories of coupling reactions, implemented in continuous reactors, and eventually applied industrially in the synthesis of biosourced ingredients.

ICN : Institut de Chimie de Nice (U. Nice Sophia Antipolis - CNRS) 
ISM : Institut des Sciences Moléculaires (U. Bordeaux - CNRS) 
IICMCB : Institut de Chimie de la Matière Condensée de Bordeaux (U. Bordeaux - CNRS) 
ICCF : Institut de Chimie de Clermont-Ferrand (U. Clermont-Ferrand - CNRS) 
LOF : Laboratory of the Future (U. Bordeaux - CNRS - Solvay) 
E2P2L : Eco-Efficient Products & Processes Laboratory (CNRS - Solvay - ENS Lyon - East China Normal University)

Hydroalkoxylation of olefins (2012-2016)

Collab. with Dr Mathieu Pucheault - ISM Bordeaux

The transfer of catalytic hydroalkoxylation reactions of olefins from homogeneous to heterogeneous conditions has been studied using Montmorillonite (MMT) doped with metal cations. In the case of intramolecular reactions, 38-99% yields of cyclic ethers have been obtained using Fe-MMT and Bi-MMT both in CH3NO2 and dimethylcarbonate (DMC) compared with other supported metals salts or metal nanoparticles. In the case of more challenging intermolecular reactions, conversions up to 72% and yields up to 54% were obtained with metal-doped MMT as well, such as Fe-, Bi-, and Ti-MMT. These catalytic systems were shown to be highly recyclable and amenable to flow chemistry.

I. Notar Francesco, B. Cacciuttolo, M. Pucheault, S. Antoniotti. Simple metal salts supported on Montmorillonite as recyclable catalysts for intramolecular hydroalkoxylation of double bonds in conventional and VOC exempt solvents. Green Chem. 2015, 17 (2), 837 - 841. Link.

I. Notar Francesco, B. Cacciuttolo, O. Pascu, C. Aymonier, M. Pucheault, S. Antoniotti. Simple salts of abondant metals (Fe, Bi, and Ti) supported on Montmorillonite as efficient and recyclable catalysts for regioselective intramolecular and intermolecular hydroalkoxylation reactions of double bonds and tandem processes. RSC Advances, 2016, 6, 19807 - 19818. Link.

Multicatalytic processes based on Au NP catalysis

The project is aimed at developing novel atom- and step-economic reactions catalysed by metal nanoparticles. The philosophy is to merge homogenous and heterogeneous catalysis to get the advantages of both (basically selectivity and recyclability).

A current project we are working on deals with the setup of multicatalytic reactions, either fully orthogonal, sequential one-pot or in continuous flow. High level of atom- and step-economy can be achieved by these approaches.

Minireview article: I. Notar Francesco, F. Fontaine-Vive, S. Antoniotti. Synergies in the catalytic activity of bimetallic nanoparticles and new synthetic methods for the preparation of fine chemicals. ChemCatChem, 2014, 6, 10, 2784-2791. Link.

Book chapter: P. D. Giorgi, S. Antoniotti. Catalytic tandem reactions triggered by the introduction of a carbonyl function. Advances in Organic Synthesis, Ed. Atta-ur-Rahman, 2018, 8, 1-31 (Invitation). Link.

Novel radical tandem 1,6-enynes thioacylation / cyclisation catalysed by Au-Pd nanoparticles

Collab. with Prof. Graham J. Hutchings - Cardiff Catalysis Institute

We studied the reactivity of 1,6-enynes with thioacetic acid (AcSH) under either thermal conditions or in the presence of catalytic amounts of supported Au or Au-Pd nanoparticles (NPs) under mild conditions. The 1,6-enynes undergo a tandem thioacylation / cyclisation to original cyclic products featuring either a homoallylic thioester function or an enol thioester function depending on the substrate topology. Interestingly, the former process was found more efficient when performed in the presence of Au-Pd NPs while the latter process can be efficiently carried out under thermal conditions (100 °C). The reaction proceeds by a radical mechanism and the presence of precious metal NPs seems to stabilise the formation of free radical intermediates, as supported by experimental and theoretical results.

I. Notar Francesco, J. Giauffret, F. Fontaine-Vive, J. K. Edwards, C. J. Kiely, G. J. Hutchings, S. Antoniotti. Novel radical tandem 1,6-enynes thioacylation / cyclisation : Au-Pd nanoparticles catalysis versus thermal activation as a function of the substrate specificity. Tetrahedron, 2014, 70, 51, 9635–9643. Link

Multicatalytic reactions en route to the one-pot total synthesis of complex molecules

A first example was recently published with an easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates catalysed by Au NPs and simple bases.

P. D. Giorgi, P. J. Miedziak, J. K. Edwards, G. J. Hutchings, S. Antoniotti. Bicatalytic multistep reactions en route to the one-pot total synthesis of complex molecules : easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates. ChemCatChem 20179, 1, 70-75.. Cover picture. Link. Highlighted by Wiley in Hot topics : sustainable chemistry.

P. D. Giorgi, N. Elizarov, S. Antoniotti. Selective oxidation of activated alcohols by supported gold nanoparticles under an atmospheric pressure of O2 : batch and continuous flow studies. ChemCatChem 2017, accepted article DOI : 10.1002/cctc.201700179. Link.

We further developed an efficient access to original cannabinoids by combining different types of solid catalyst in continuous flow: P. D. Giorgi, V. Liautard, M. Pucheault, S. Antoniotti. Biomimetic Cannabinoid Synthesis Revisited: Batch and Flow All‐Catalytic Synthesis of (±)‐ortho‐Tetrahydrocannabinols and Analogues from Natural Feedstocks. Eur. J. Org. Chem201811, 1307-1311. Cover picture. Link.

couvEurJOC

Innovative fragrance ingredients

Review article : S. Antoniotti. Tuning of essential oils properties by enzymatic treatment : Towards sustainable processes for the generation of new fragrant ingredients. Molecules, 2014, 19(7), 9203-9214. (Invitation) OPEN ACCESS.

Essenzyme project

Labelised by cluster PASS

Funded by APRF CR PACA

The project Essenzyme is a collaborative project between our group and two French companies, aimed at developping mild enzymatic protocols for the tuning of essential oils properties by modification of their chemical composition. It is divided in several sub-projects, one for the design of novel fragrance ingredients, and the second for the production of detoxified essential oils.

Natural vetiver acetate project

Funded by SATT sud-est

Development of an industrial process for the manufacture of natural vetiveryl acetate for the perfume industry. European patent pending.

I. Notar Francesco, J.-J. Filippi, S. Antoniotti. Sustainable manufacture of a valuable fragrance ingredient : Lipase-catalysed acylation of vetiver essential oil and chemoselectivity between sesquiterpene alcohols. ChemPlusChem201782, 3, 407-415. DOI : 10.1002/cplu.201600617. Link. Highlighted in the Wiley Hot topics : biocatalysis.

Natural atranol-free oakmoss extracts

Funded by SATT sud-est

Development of an enzymatic process for the removal of atranol and related toxic compounds from oakmoss extracts. European patent pending.

H. Bouges, A. Monchot, S. Antoniotti. Enzyme-catalysed conversion of atranol and derivatives into dimeric hydrosoluble materials. Application to the preparation of a low-atranol oakmoss absolute. Cosmetics 20185(4), 69Link.

Discovery and total synthesis of fragrance ingredients by innovative technologies

Funded by Alysophil

Optimisation of the properties of natural complex substances used in perfumery by enzymatic treatments

Funded by IFF-LMR and Région PACA

Labelised by cluster PASS

Assessment of the naturally of essential oils by innovative approaches 

Funded by Pharmapur and IDEXJEDI

GDRO3 : French transdisciplinary research network on odorants, odours and olfaction https://gdro3.wordpress.com/


 

70. ---- H. Bouges, A. Monchot, S. Antoniotti. Enzyme-catalysed conversion of atranol and derivatives into dimeric hydrosoluble materials. Application to the preparation of a low-atranol oakmoss absolute. Cosmetics 2018, 5(4), 69. Link.

69. ---- H. Bouges, K. Calabro, O. P. Thomas, S. Antoniotti. Unusual polycyclic fused product by oxidative enzymatic dimerisation of 5-methylpyrogallol catalyzed by horseradish peroxidase/H2O2. Molecules 2018, 23(10), 2619. Link.

Nicenolide

68. ---- N. Elizarov, P. D. Giorgi, A. Yeromina, S. Antoniotti. Complex molecules synthesis made easy. Proceedings of the 1st UCA days 2018

67. ---- P. D. Giorgi, V. Liautard, M. Pucheault, S. Antoniotti. Biomimetic Cannabinoid Synthesis Revisited: Batch and Flow All‐Catalytic Synthesis of (±)‐ortho‐Tetrahydrocannabinols and Analogues from Natural Feedstocks. Eur. J. Org. Chem. 2018, 11, 1307-1311. Cover picture. Link.

 couvEurJOC

 

66. ---- P. D. Giorgi, S. Antoniotti. Catalytic tandem reactions triggered by the introduction of a carbonyl function. Advances in Organic Synthesis, Ed. Atta-ur-Rahman, 2018, 8, 1-31 (Invitation). Link.


65. ---- X. Fernandez, S. Antoniotti, J. Golebiowski. Ingrédients odorants et design olfactif. In: La chimie et les sens, 2018, Dunod (Paris). Link.


64. ---- S. Antoniotti, J.-G. Boiteau. Réactifs nucléophiles organométalliques en synthèse organique. Théorie et applications. Tech. Ing2018, AF6511. Link.


63. ---- P. D. Giorgi, S.-H. Soo-Tang, S. Antoniotti, J. C. van der Waal. Catalytic oxidation of biosourced 3-methylphtalic anhydride under O2: one-pot hemimellitic acid synthesis and novel example of biomass valorization. ChemistrySelect2017 , 2, 33, 10766–10770. Link


62. ---- B. Touati, A. El Bouakher, M. Salah Azizi, C. Taillier, R. Ben Othman, M. Trabelsi-Ayadi, S. Antoniotti, E. Duñach, V. Dalla. Atom-economical catalytic direct substitution of N,O-acetals with simple ketones. Eur. J. Org. Chem2017, 30, 4445-4460. Link


61. ---- I. Notar Francesco, J.-J. Filippi, S. Antoniotti. Sustainable manufacture of a valuable fragrance ingredient: Lipase-catalysed acylation of vetiver essential oil and chemoselectivity between sesquiterpene alcohols. ChemPlusChem201782, 3, 407-415. Link. Highlighted in the Wiley Hot topics : biocatalysis. 


60. ---- H. Bouges, S. Antoniotti. Synthesis of deuterated methyleugenol via transition metal-catalysed coupling of substituted deuterated benzyl chloride with vinylmagnesium bromide. Flavour Fragr. J., 201732, 3, 191-195. Link


59. ---- P. D. Giorgi, N. Elizarov, S. Antoniotti. Selective oxidation of activated alcohols by supported gold nanoparticles under an atmospheric pressure of O2: batch and continuous flow studies. ChemCatChem 2017, 9, 10, 1830-1836. Link. Highlighted by Wiley in Hot topics : gold. 


58. ---- P. D. Giorgi, P. J. Miedziak, J. K. Edwards, G. J. Hutchings, S. Antoniotti. Bicatalytic multistep reactions en route to the one-pot total synthesis of complex molecules: easy access to chromene and 1,2-dihydroquinoline derivatives from simple substrates. ChemCatChem 2017, 9, 1, 70-75. Link. Cover picture. Highlighted by Wiley in Hot topics : sustainable chemistry.




57. ---- N. Elizarov, M. Pucheault, S. Antoniotti. Highly efficient Hosomi-Sakurai reaction of aromatic aldehydes catalyzed by Montmorillonite doped with simple bismuth(III) salts. Batch and continuous flow studies. ChemistrySelect 20161, 12, 3219-3222. Link


56. ---- S. Antoniotti. Catalyse par des nanoparticules métalliques. Techniques de l’ingénieur, 2016, AF6508. 


55. ---- X. Fernandez, S. Antoniotti. Parfums : matières premières, formulations et applications. Techniques de l’ingénieur, 2016, J2304. 


54. ---- L. Laurençon, T. K. T. Do, F. Hadji-Minaglou, S. Antoniotti, X. Fernandez. Fast and efficient chromatographic methods for quantification of total saponins in Solidago virgaurea L. ssp. extracts. Comparison of high pressure liquid chromatography and high performance thin-layer chromatography. J. Planar Chrom201629, 6, 410–416. 


53. ---- B. Touati, A. El Bouakher, C. Taillier, R. Ben Othman, M. Trabelsi-Ayadi, S. Antoniotti, E. Dunach, V. Dalla. Enolizable carbonyls and N,O-acetals: A rational approach for room-temperature Lewis superacid-catalyzed direct α-amidoalkylation of ketones and aldehydes. Chem. Eur. J. 201622, 17, 6012–6022. Link


52. ---- I. Notar Francesco, B. Cacciuttolo, O. Pascu, C. Aymonier, M. Pucheault, S. Antoniotti. Simple salts of abundant metals (Fe, Bi, and Ti) supported on Montmorillonite as efficient and recyclable catalysts for regioselective intramolecular and intermolecular hydroalkoxylation reactions of double bonds and tandem processes. RSC Advances20166, 19807 - 19818. Link


51. ---- I. Notar Francesco, B. Cacciuttolo, M. Pucheault, S. Antoniotti. Simple metal salts supported on Montmorillonite as recyclable catalysts for intramolecular hydroalkoxylation of double bonds in conventional and VOC exempt solvents. Green Chem201517 , 2, 837 - 841. Lien


50. ---- T. K. T. Do, F. Hadji-Minaglou, S. Antoniotti, X. Fernandez. Essential oil authenticity: a challenge for the analytical chemist. Trends Anal. Chem. 201566, 146–157. Lien


49. ---- I. Notar Francesco, J. Giauffret, F. Fontaine-Vive, J. K. Edwards, C. J. Kiely, G. J. Hutchings, S. Antoniotti. Novel radical tandem 1,6-enynes thioacylation / cyclisation: Au-Pd nanoparticles catalysis versus thermal activation as a function of the substrate specificity. Tetrahedron 201470, 51, 9635–9643. Lien


48.---- S. Antoniotti. Tuning of essential oils properties by enzymatic treatment: Towards sustainable processes for the generation of new fragrant ingredients. Molecules 201419, 7, 9203-9214. (Invitation) OPEN ACCESS


47. ---- I. Notar Francesco, F. Fontaine-Vive, S. Antoniotti. Synergies in the catalytic activity of bimetallic nanoparticles and new synthetic methods for the preparation of fine chemicals. ChemCatChem 20146, 10, 2784-2791. Lien


46. ---- K. Ben Hadj Hassen, K. Gaubert, M. Vaultier, M. Pucheault, S. Antoniotti. Comparison of homogeneous and heterogeneous Ga(III)-catalysis in the cycloisomerisation of 1,6-enynes. Green Chem. Lett. Rev. 20147, 3, 243-249. OPEN ACCESS


45. ---- T. K. T. Do, F. Hadji-Minaglou, S. Antoniotti, X. Fernandez. Secondary metabolites isolation in natural products chemistry: comparison of two semipreparative chromatographic techniques (HPLC and HPTLC). J. Chrom. A 20141325, 256–260. Lien


44. ---- P. Nava, Y. Carissan, J. Drujon, F. Grau, J. Godeau, S. Antoniotti, E. Duñach, S. Humbel. Theoretical study of the catalysis of the cycloisomerisation of 1,6-dienes with Sn(IV) salts: important role of a water molecule. ChemCatChem 20146, 2, 500-507. Lien. Inside cover.




43. ---- J. Ramilijaona, E. Raynaud, C. Bouhlel, E. Sarrazin, X. Fernandez, S. Antoniotti. Enzymatic modification of palmarosa essential oil: chemical analysis and olfactory evaluation of acylated products. Chem. Biodiv201310, 12, 2291–2301. Lien


42. ---- J. Godeau, F. Grau, S. Antoniotti, E. Duñach. Preparation and olfactory evaluation of mono- and bicyclic compounds featuring gem-dimethylcyclohexane structures. Flavour Fragr. J201329, 1, 59–66. Lien


41. ---- R. Belaqziz, F. Bahri, A. Romane, S. Antoniotti, X. Fernandez, E. Duñach. Essential oil composition and antibacterial activity of the different parts of Thymus maroccanus Ball: an endemic species in Morocco(†). Nat. Prod. Res201327, 18, 1700-1704. Lien


40. ---- S. Antoniotti. Chimie verte - Chimie durable. Ellipses (Paris) 2013, pp 192. Lien.




39. ---- S. Antoniotti, M. Abert Vian, F. Chemat. Les huiles essentielles comme ingrédients pour une chimie « verte ». In : Fernandez, Chemat (Eds) : La chimie des huiles essentielles, 2012, Vuibert (Paris). Lien


38. ---- J. Godeau, F. Fontaine-Vive, S. Antoniotti, E. Duñach. Experimental and theoretical studies of the bismuth triflate-catalysed cycloisomerisation reaction of 1,6,10-trienes and aryl polyenes. Chem. Eur. J.201218, 52, 16815-16822. Lien.




37. ---- V. Vece, K. Ben Hadj Hassen, S. Antoniotti, E. Duñach. C-O and C-C bonds formation in the cyclisation of gem-(dialkoxymethyl)-1,6-dienes catalysed by tin(IV) triflimidate at room temperature. Tetrahedron Lett201253, 38, 5102-5105. Lien. Abstracted in Cheminform


36. ---- C. Bouhlel, G.’A. Dolhem, X. Fernandez, S. Antoniotti. Model study of the enzymatic modification of natural extracts: peroxidase-based removal of eugenol from rose essential oil. J. Agric. Food Chem201260, 4, 1052-1058. Lien


35. ---- A.-L. Groussin, S. Antoniotti. Valuable chemicals by the enzymatic modification of molecules of natural origin: terpenoids, steroids, phenolics and related compounds. Bioresource Technol2012115, 237-243. Lien


34. ---- O. Thomas, S. Antoniotti. Exercices et QCM de chimie organique UE1. Collection PACES, 2011, Ellipses (Paris). Lien


33. ---- O. Thomas, S. Antoniotti. Cours de chimie organique UE1. Collection PACES, 2011, Ellipses (Paris). Lien


32. ---- G. Genta-Jouve, S. Antoniotti, O. P. Thomas. Polyketide assembly mimics and biomimetic access to aromatic rings. In : Poupon, Nay (Eds) : Biomimetic Organic Synthesis, 2 Vol., 2011, Wiley-VCH Verlag (Weinheim). Lienvers le site de Wiley. Abstracted in Cheminform





Highlighted in Angew. Chem. Int. Ed201251, 583. Lien


31. ---- J. Godeau, S. Olivero, S. Antoniotti, E. Duñach. Biomimetic cationic polyannulation reaction catalyzed by Bi(OTf)3: cyclization of 1,6-dienes, 1,6,10-trienes and aryl trienes. Org. Lett201113, 13, 3320-3323. Lien. Highlighted in Methods in Organic Synthesis abstracts and in Catalysts and Catalysed Reactions abstracts. Abstracted in Cheminform


30. ---- S. Antoniotti, S. Poulain-Martini, E. Duñach. Electrophilic functionalization of non-activated olefins catalyzed by Lewis superacids. Synlett 2010, 2973-2988. Lien. Abstracted in Cheminform


29. ---- S. Antoniotti, V. Dalla, E. Duñach. Metal Triflimidates : better than Metal Triflates as Catalysts in Organic Synthesis-the Effect of a Highly Delocalised Counter-Anion. Angew. Chem. Int. Ed201049, 43, 860-7888. Lien. Highlighted in Catalysts and Catalysed Reactions abstracts and in Methods in Organic Synthesis abstracts. Abstracted in Cheminform.




28. ---- R.-M. Dia, R. Belaqziz, A. Romane, S. Antoniotti, E. Duñach. Flavouring and odorant thiols from renewable resources by InIII-catalysed hydrothioacetylation and lipase-catalysed solvolysis. Tetrahedron Lett201051, 16, 2164-2167. Lien. Abstracted in Cheminform


27. ---- R. Ben Othman, R. Affani, M.-J. Tranchant, S. Antoniotti, V. Dalla, E. Duñach. N-Acyliminium ions chemistry : highly efficient and versatile carbon-carbon bond formation by nucleophilic substitution of hydroxyl groups catalyzed by Sn(NTf2)4. Angew. Chem. Int. Ed201049, 776-780. HOT PAPER. Lien. Highlighted in Catalysts and Catalysed Reactions abstracts and in Methods in Organic Synthesis abstracts. Abstracted in Cheminform.




26. -----S. Antoniotti, E. Duñach. Tin(IV) triflimidate-catalyzed cyclization of epoxy esters to functionalized δ-hydroxy-γ-lactones. Tetrahedron Lett200950, 21, 2536-2539. Lien. Highlighted in Methods in Organic Synthesis abstracts. Abstracted in Cheminform


25. -----S. Antoniotti. 4th French-Italian Chemistry Congress : Environment and Sustainable Development. C. R. Chim200912, 8, 829-830. Lien


24. -----J. Godeau, S. Olivero, S. Antoniotti, E. Duñach. Lewis superacids derived from triflic and triflimidic acids and their use as catalysts in 1,6-dienes cycloisomerisation. C. R. Chim. 200912, 8, 911-915 . Lien


23. -----X. Fernandez, S. Antoniotti, E. Bussotti, M.-P. Hurel. Parfum, chimie et création. Actual. Chim2008, 323-324, 42-51. Lien.




22. -----P. Y. Toullec, E. Genin, S. Antoniotti, J.-P. Genêt, V. Michelet. Au2O3 as a highly stable and efficient catalyst for the selective cycloisomerisation of -acetylenic carboxylic acids to -alkylidene -butyrolactones. Synlett 2008, 707-711. Lien. Highlighted in the Organic Chemistry Portal, in Catalysts and Catalysed Reactions abstracts and in Methods in Organic Synthesis abstracts. Abstracted in Cheminform


21. -----S. Antoniotti, X. Fernandez, E. Duñach. Substrate scope evaluation of hydrolases and enzymatic reaction design. Biocatal. Biotransfor200826, 3, 228-234. Lien


20. -----S. Antoniotti, E. Duñach. Facile preparation of metallic triflates and triflimidates by oxidative dissolution of metal powders. Chem. Comm2008, 993-995. Lien


19. -----P. Lemechko, F. Grau, S. Antoniotti, E. Duñach. Hydroalkoxylation of non-activated olefins catalysed by Lewis superacids in alcoholic solvents : An eco-friendly reaction. Tetrahedron Lett. 200748, 5731-5734. Lien. Abstracted in Cheminform

L’introduction de cet article a été plagiée dans un article paru 2 ans plus tard. Plagiarism of the introduction of his article occured 2 years after in : Tetrahedron Letters, 2009, 50, 5783-5785. Lien


18. -----F. Berrué, S. Antoniotti, O. Thomas, P. Amade. Bioinspired metal-catalysed Doebner - Knoevenagel condensations between malonic acid half thioesters and aldehydes. Eur. J. Org. Chem. 200711, 1743-1748 . Lien. Highlighted in Catalysts and Catalysed Reactions abstracts. Abstracted in Cheminform


17. -----E. Genin, P. Y. Toullec, P. Marie, S. Antoniotti, C. Brancour, J.-P. Genêt, V. Michelet. Gold catalysis in organic synthesis : efficient intramolecular cyclization of gamma-acetylenic carboxylic acids to 5-exo-alkylidene-butyrolactones. ARKIVOC 2007V, 67-78. Lien


16. -----R. F. Klees, P. C. De Marco, R. M. Salasznyk, D. Ahuja, M. G. Hogg, S. Antoniotti, L. Kamath, J. S. Dordick, G. E. Plopper. Apocynin derivatives interrupt intracellular signalling resulting in decreased migration in breast cancer cell.  J. Biomed. Biotechnol. 2006, 1-10. Lien


15. -----S. Antoniotti, J. Golebiowski, D. Cabrol-Bass, E. Duñach. Density Functional Theory investigations on acid-catalysed epoxide oxidative ring-opening by DMSO. Competition between oxidation processes. J. Mol. Struct. (Theochem) 2006763, 155-9. Lien


14. ------E. Genin, P. Y. Toullec, S. Antoniotti, C. Brancour, J.-P. Genêt, V. Michelet. Room Temperature Au(I)-Catalyzed exo-Selective Cycloisomerization of Acetylenic Acids : An Entry to Functionalized -Lactones. J. Am. Chem. Soc2006128, 3112-3113. Lien. Highlighted in the Organic Chemistry Portal. Abstracted in Cheminform

*** Ranked in the JACS most-cited articles in 2006 *** 

as of December 31, 2006 (#13) 

as of December 31, 2007 (#20) 


13. ------E. Genin, S. Antoniotti, V. Michelet, J.-P. Genêt. An Ir(I)-catalyzed exo-selective tandem cycloisomerization / hydroalkoxylation of bis-homopropargylic alcohols at room temperature. Angew. Chem. Int. Ed. 200544, 4949-53. Lien. Highlighted in Catalysts and Catalysed Reactions abstracts. Abstracted in Cheminform


12. ------S. Antoniotti, E. Genin, V. Michelet, J.-P. Genêt. Highly efficient access to strained bicyclic ketals via gold-catalyzed cycloisomerization of bis-homopropargylic diols. J. Am. Chem. Soc2005127, 9976-9977. Lien. Highlighted in Methods in Organic Synthesis abstracts. Abstracted in Cheminform


11. ------S. Antoniotti, J. S. Dordick. Peroxidase-catalyzed coupling of solid-supported ortho-methoxyphenols. Adv. Synth. Catal. 2005347, 1119-24. Lien


10. ------S. Antoniotti, S. Antonczak, J. Golebiowski. Acid-catalysed oxidative ring-opening of epoxide by DMSO. Theoretical investigation of the effect of acid catalysts and substituents. Theor. Chem. Acc. 2004112, 290-7. Lien


9. ------S. Antoniotti, E. Duñach. Mechanistic aspects of the Bi-catalysed oxidation of epoxides to -diketones. Eur. J. Org. Chem. 2004, 3459-64. Lien. Highlighted in Catalysts and Catalysed Reactions abstracts


8. ------S. Antoniotti, E. Duñach. Utilisations récentes de dérivés du bismuth en synthèse organique. Comptes Rendus Chimie 20047, 679-88. Lien. Abstracted in Cheminform


7. ------S. Antoniotti, N. Alezra, X. Fernandez, E. Duñach. Catalytic epoxide oxidation : a novel access to various flavouring and odorant -diketones. Flavour Frag. J. 200419, 373-81. Lien. Highlighted in Methods in Organic Synthesis abstracts


6. ------S. Antoniotti, L. Santhanam, D. Ahuja, M. G. Hogg, J. S. Dordick. Structural diversity of peroxidase-catalyzed oxidation products of ortho-methoxyphenols. Org. Lett. 20046, 1975-8. Lien


5. ------S. Antoniotti, E. Duñach. Studies on the catalytic oxidation of epoxides to alpha-diketones by Bi(0)/O2 in DMSO. J. Mol. Catal. A 2004208, 135-45. Lien


4. ------S. Antoniotti, E. Duñach. Epoxide oxidations : a valuable tool in organic synthesis. Synthesis 2003, 2753-62. Lien. Highlighted in Methods in Organic Synthesis abstracts. Abstracted in Cheminform


3. ------S. Antoniotti. Bismuth(III) trifluoromethanesulfonate. Synlett 2003, 1566-7. Lien. *** Ranked in the 5 most cited Synlett spotlights over 10 years (see here). *** 


2. ------S. Antoniotti, E. Duñach. Direct and catalytic synthesis of quinoxaline derivatives from epoxides and ene-1,2-diamines. Tetrahedron Lett200243, 3971-3. Lien. Highlighted in Methods in Organic Synthesis abstracts. Abstracted in Cheminform


1. ------S. Antoniotti, E. Duñach. Novel and catalytic oxidation of internal epoxides to -diketones. Chem. Commun. 2001, 2566-7. Lien. Abstracted in Cheminform.

Master training available :

No position at the moment.

PhD position available :

No opening for 2019.

Scientist position :

No opening.

Send a CV and cover letter along with the references of three persons by email at :

Dr Sylvain ANTONIOTTI

Université Cote d'Azur

Institut de Chimie de Nice, CNRS, Parc Valrose 06108 Nice Cedex 02 FRANCE

Tel : +33(0)4 92 07 61 72 

E-Mail : sylvain.antoniotti@unice.fr

Spontaneous applications for trainings, PhD thesis or post-doctoral positions are welcome. However, we might not be able to answer individually to everybody. Apologies.


1st Master class NiceFlow

Masterclass NiceFlow

University Nice Sophia Antipolis – Faculty of Sciences – Parc Valrose – Nice, France

Université Nice Côte d’Azur will host the 1st Masterclass NiceFlow on the applications of flow chemistry in modern synthetic organic chemistry on Friday 7th April 2017. The philosophy of this event is to provide flow chemistry users with relevant data, examples and tips from european experts of the field. To facilitate the exchange of ideas and ensure an unformal and friendly atmosphere, only a limited number of participants will be registered.

See you soon in Nice ! Dr Sylvain Antoniotti.

Provisional program

  • 8.30 am Welcome – registration – coffee
  • 9.00 am Opening words
  • 9.15 am Lecture #1 : Dr Mathieu Pucheault, Institut des Sciences Moléculaires, U. Bordeaux. Flow chemistry, from lab curiosities to pilot application.
  • 10.45 am Questions – discussion with the audience
  • 11.00 am Coffee break
  • 11.15 am Lecture #2 : Dr. Kerry Gilmore, Max Planck Institute of Colloids and Interfaces, Potsdam.Controlled, Modular Chemistry.
  • 12.45 am Questions – discussion with the audience
  • 1.00 pm Lunch – buffet
  • 2.30 pm Lecture #3 : Dr Duncan L. Browne, School of Chemistry, Cardiff University. From Basics to the Cutting-Edge : A Workshop on Continuous Flow Chemistry.
  • 4.00 pm Questions – discussion with the audience
  • 4.15 pm Coffee break
  • 4.30 pm Presentation from Vapourtec : Dr Ryan Skilton, Suffolk, United Kingdom. Exploring some recent literature and applications using the Vapourtec systems and an introduction to the E-Series and some of the available reactors.
  • 5.30 pm Questions – discussion with the audience
  • 5.45 pm Concluding remarks
  • 6.00 pm Wine & cheese session

Contact : sylvain.antoniotti@unice.fr

Registration (limited number of participants) : https://www.azur-colloque.fr/DR20/i...

Supported by : 


Juillet 2013 July

Septembre 2014 September

Condenser without water circulation

VOC emission-free vacuum pump

Two parallel reactors 12-slots



Vapourtec flow chemistry system R-series (4 pumps, UV detector and fraction collector)