Rentrée 2026 de l'Académie 4 "Complexité et diversité du vivant"

Vous êtes cordialement invités à la réunion de Rentrée de l'Académie 4 qui se tiendra le vendredi 17 Octobre à 9h30 en salle de conférence de l'IPMC à Sophia Antipolis. Les projets sélectionnés en Juin et septembre derniers seront présentés par les porteurs. 
You are cordially invited to the Academy 4 Welcome Meeting, which will take place on Friday, October 17, at 9:30 a.m. in the conference room at IPMC in Sophia Antipolis. The projects selected last June and September will be presented by the project leaders.


Modérateur: Guillaume Drin, président du conseil scientifique de l'Académie 4 
Chairperson: Guillaume Drin, président of the scientific council of the Academy 4


Programme

8h30 Accueil / opening

9h00 Le mot de Pascal Barbry, coordinateur de l'Académie 4  / Opening remarks by Pascal BARBRY, Coordinator of Academy 4

9h10 DravNet - Network Mechanisms of Brain Dysfunction in Dravet Syndrome
By Fabrizio Capitano, IPMC & Etienne Tanre, INRIA 
Partners: Massimo Mantegazza, Patricia Reynaud Bouret
Key words: Epilepsy, Dravet Syndrome, Electrophysiology, Stochastic models, States transition, Functional connectivity

9h30 SEMANTICROSS - Neurocognitive mechanisms underlying semanticization across species
By Ingrid Bethus, IPMC & Raphaël Fargier, BCL
Key words: Neural basis of cognition, systems and computational neuroscience, learning, semantic, language

9h50 PRIMA - Protein Redesign with Immunogenicity Mitigation Algorithms
By Patrick Brest, IRCAN & Edoardo Sarti, INRIA
Partners: Frédéric Cazals, Olivier Croce & Christina Cayron
Key words: Shared epitopes, Computational de-immunogenisation, reporter proteins, Protein language models, Differential tissue expression, Rational design, arDCA, Predictive immunogenicity

10h10 TripMod - Resource allocation modelling in a multi-trophic plant-symbiont-pest system
By Pierre Frendo, ISA & Valentina Baldazzi, INRIA
Key words: Nitrogen fixing symbiosis, pea, Rhizobium leguminosarum, pea aphid, modelling.

10h30 SAMBA - Symbiodiniaceae Attraction in Marine Behavioral Analysis
By Stéphanie Barnay-Verdier, Campus Valrose & Philippe Thomen, INPHYNI
Partners: Paola Furla ; Thamilla Zamoum ; Mohamed Mehiri
11h10 SPLENOCODE - Decoding the splenic neural code of inflammation: a transdisciplinary pilot towards nerve-based, real-time biomarkers of inflammatory disease activity
By Philippe Blancou, IPMC &  Olivier Meste, I3S
Key words:  bioelectronic medicine; neuro-immune interface; splenic nerve; neurogram; peripheral nerve decoding; real-time biomarker; machine learning; biomedical signal processing; rheumatoid arthritis; sympathetic drive; interspike intervals.

11h30 SERPIDUO - From Chemical Screening to Biological Validation: An Interdisciplinary Approach to Developing Novel SERPINE1 Inhibitors to Overcome Immunotherapy Resistance in Renal Cancer 
By Maeva Dufies, IRCAN & Cyril Ronco, ICN
Key words:  SERPINE1/PAI-1 ; carcinome rénal à cellules claires ; immunothérapie anti-PD-1; chimie médicinale ; inhibiteur pharmacologique

11h50 NUC-MECH-MEL - Nuclear deformation and mechanical modelling of melanoma phenotypic plasticity
By Mickael Ohanna, C3M &  Rachele Allena, LJAD
Partners : Emmanuèle Helfer-Cozic, CNRS Research Director, Aix-Marseille Université, CINaM
Key words:  Melanoma; phenotypic plasticity; LMNB2; nuclear envelope remodeling; nuclear deformability; confined migration; mechanobiology; mechanical modelling; therapy resistance; interdisciplinary training.

12h10 MorphoZIP - Testing an adhesion-mediated zipper during Drosophila mesoderm internalization
By  Matteo Rauzi, iBV & Grégoire Malandain, i3S
Key words : Drosophila gastrulation; mesoderm internalization; zippering; E-cadherin; apical-basal polarity; 4D segmentation; mechanobiology



12h30 Discussions autour d'un buffet offert par l'Académie 4, en extérieur si le temps le permet / Discussions over a buffet provided by Académie 4; outdoors, weather permitting.