Axes de recherche

L'IDEX UCA^JEDI s’articule autour de plusieurs structures, dont 5 «académies d’excellence » qui ont pour mission de créer et favoriser l’émergence de nouvelles dynamiques scientifiques transdisciplinaires fortes, capables de devenir des pôles de référence en matière de Recherche, Formation et Innovation.

Les 5 académies recouvrent en elles-mêmes des thématiques transdisciplinaires :

Académie A1 : « Réseaux, information et société numérique »
Académie A2 : «Systèmes complexes »
Académie A3 : «Espace, environnement, risque et résilience »
Académie A4 : « Complexité et diversité du vivant»
Académie A5 : «Homme, idées et milieux »

Agenda

[REBICA 2024] REncontre annuelle BIoinformatique à Université Côte d'Azur 1er juillet 2024 INSPE NICE

Nice-Seq Seminar Series

The goal of this series is to have Crossdisciplinary Seminars from people working in NICE - VILLEFRANCHE - SOPHIA area who are interested in Next Generation Sequencing Approaches.

The first four editions were exclusively centered on Methods, Protocols, Analyses and Applications. The series are now opened to other Bio-Informatic Approaches. 
Presentations are given every 3 months by PhD students, Postdocs, Engineers and Researchers .

The venue rotates between different institutes and visioconference.

We hope that you will be interested in attending and contributing !
Press here to register to the mailing list.


ORGANISERS

Pascal BARBRY- IPMC - pascal.barbry@univ-cotedazur.fr
Christian BRAENDLE- iBV - christian.braendle@univ-cotedazur.fr
Richard COPLEY- UPMC - LBDV - richard.copley@obs-vlfr.fr
Etienne DANCHIN - ISA INRAE - etienne.danchin@inra.fr
Gianni LITI - IRCAN - gianni.liti@univ-cotedazur.fr
Michele TRABUCCHI - C3M - michele.trabucchi@univ-cotedazur.fr
Carole BARON - Université Côte d'Azur - carole.baron@univ-cotedazur.fr

ARCHIVES

• 
  17th NICE_SEQ SEMINAR SERIES, May 22nd, 3:30-5:45pm, IBV
• 
  15th NICE_SEQ SEMINAR SERIES, September 2nd 2022, 3-6:30pm, IRCAN
• 
  14th NICE_SEQ SEMINAR SERIES, September 17th 2021, 2-6pm
• 
  12th NICE_SEQ SEMINAR SERIES_March 19th 2021
• 
  11th NICE_SEQ SEMINAR SERIES_Nov 27th 2020
• 
  10th NICE_SEQ SEMINAR SERIES_April 2nd 2020
• 
  9th NICE_SEQ SEMINAR SERIES_Oct 3rd 2019
• 
  8th NICE_SEQ SEMINAR SERIES_June 28th 2019
• 
  7th NICE_SEQ SEMINAR SERIES_March 8th 2019
• 
  6th NICE_SEQ SEMINAR SERIES_Jan 11th 2019
• 
  5th NICE_SEQ SEMINAR SERIES_June 8th 2018
• 
  4th NICE_SEQ SEMINAR SERIES_March 16th 2018
• 
  3rd NICE_SEQ SEMINAR SERIES_Dec 15th 2017
• 
  2nd NICE_SEQ SEMINAR SERIES_Sept 8th 2017
• 
  1st NICE_SEQ SEMINAR SERIES_June 2nd 2017

JOBIM@UnivCotedAzur

Actualités


Archives

• 
  JOBIM 2021 à l'Université Côte d'Azur

 

Pour s'abonner à la Mailing List

Saisissez ici le contenu

Qui Sommes-Nous ?

Nous sommes un groupe de trois doctorants de différents instituts de NICE et SOPHIA-ANTIPOLIS : Hiba LAGHRISSI (iBV), Maxime MULTARI (ISA) et Paola PORRACCIOLO (IPMC &LJAD).
Nous créons, pour la première fois, une communauté pour les doctorants et étudiants dans le domaine de la Bio-Informatique sur le site d'Université Côte d'azur : BioCPU pour "Bioinformatics Community for PhDs and Undergraduates".

Nos Objectifs

DEFIS ACTUELS	OBJECTIFS
1 - Communication difficile 2 - Manque de support scientifique 3 - Difficulté à mettre en place un réseau	1 - Construire une communauté durable 2 - Attirer des Experts en Bio-Informatique dans la Région 3 - Constituer un réseau

Notre organisation

Format des réunions 

- Les présentations, en visioconférence, sont obligatoires pour les doctorants et facultatives pour les ingénieurs et les postdoctorants
- Public : toute personne intéressée
- Chaque personne présente une fois par cycle (1 cycle = 1,5 an)
- 30min par intervenant (20 ~ 25min de présentation + 5 ~ 10min de discussion)
- Les présentations seront disponibles sur le drop box de l'université
- Fréquence des réunions : mensuelles, le vendredi à 13h
- Calendrier et autres documents disponibles à l'adresse suivante: Calendrier & Infos

ABOUT US

Unraveling the mysteries of obesity, that’s the mission Adipo-Cible is pursuing.

Since November 2023, the consortium has officially brought together 21 fundamental and clinical research teams and one start-up toward a common goal: to understand why the adipose tissue dysfunctions in individuals with obesity and to develop personalized treatment for the disease.

The aim of ADIPOCIBLE is to be an international actor focusing on the adipose tissue dysfunction especially on the inflammation and fibrosis development

1- Obesity, a complex chronic disease

With more than one billion people suffering from obesity worldwide, it has become the most common chronic disease. The prevalence of obesity has continued its steep rise in the last decades, globally doubling among adults since 1990, and quadrupling among teenagers.

The World Health Organization defines obesity as a multifactorial, hence complex chronic disease as it involves an excessive deposition of adipose tissue that may harm the health. Indeed, people suffering from obesity are at risk of developing numerous pathologies such as cardiovascular diseases, type 2 diabetes, and certain types of cancer, which not only contribute to the world morbidity and mortality, but also impose a substantial economic burden.

Although therapeutic strategies have recently advanced, managing obesity remains complex and often ineffective due to the multifaceted nature of the disease. Notably, long-term results from dietary and physical activity modifications are modest. Therefore, it is urgent to identify the physiological factors underlying this disease at the genetic, cellular, and molecular levels to stem the rising number of cases.

2-  Stronger together

The Adipo-Cible research group aims to deepen the understanding of obesity through a multidisciplinary approach. Adipo-Cible unites researchers from diverse fields, including biology, chemistry, and mathematics, to establish a continuum of fundamental, translational, and clinical research around three main objectives:

- To unravel the mechanisms involved in adipose tissue dysfunction.
- To identify biomarkers of weight regain after metabolic and bariatric surgery and develop personalized treatments using predictive algorithms.
- To develop personalized nutritional and exercise programs, as well as surgical and endoscopic interventions, utilizing artificial intelligence to enhance and sustain weight loss efficacy.

 

ORGANIZATION

Two co-directors:

- Pr Antonio Iannelli
- Pr Christian Roux.

A Scientific Advisory Board:

- Pr A Iannelli,
- Pr CH Roux,
- Dr M Cormont,
- Dr EZ Amri,
- Dr P Tanti,
- Dr P Gual,
- Pr F Cherikh
- Dr V Lanoue.

The people:

- 7 clinicians and their team,
- 13 fundamental and transversal research teams,
- 1 start-up.

RESEARCH

1. Our Clinicians

- Rodolphe Anty - Thierry Bège - Faredj Cherikh - Nicolas Chevalier - Antonio Iannelli - Christian Roux - Stéphane Schneider - Geoffroy Vanbiervliet

2. Our Biologists

- Cellular and Molecular Regulation of Fat Mass (CMRFM), iBV http://ibv.unice.fr/research-team/amri/

- Genomics & Evolution in Neuro-Endocrinology (GENE), IPMC https://www.ipmc.cnrs.fr/cgi-bin/site.cgi

- ImmunoSurveillance in Aging & Cancer (ISAC), IRCAN https://www.ircan.org/en/research/julien-cherfils-vicini

- Maintaining Autonomy, LAMHESS https://lamhess.univ-cotedazur.fr/projets-scientifiques/maintien-de-lautonomie

- Chronic Liver Diseases Associated with Obesity and Alcohol (LIVDISEASES), C3M https://www.c3m-nice.fr/en/Teams/team-08

- Myeloid Cell Immunometabolism (MCI), LP2M https://lp2m.univ-cotedazur.fr/axes-de-recherche/cellules-myeloides-et-metabolisme

- Insulin Resistance in Obesity and Type 2 Diabetes (IROD), C3M https://www.c3m-nice.fr/equipes/equipe-07/

- Vessel Formation in Development and Disease (VFDD), iBV http://ibv.unice.fr/research-team/wagner/

3. Our Chemists

- Chemical Senses and Simulations (ChemSenSim), ICN https://lab.chemsensim.fr/

4. Our Mathematicians

- Signaux, Images et Systèmes (SIS), i3S https://www.i3s.unice.fr/fr/axes-de-recherche/sis

- Analysis and Control of Unsteady Models in Engineering Sciences (ACUMES), INRIA https://team.inria.fr/acumes/

- 3IA https://3ia.univ-cotedazur.eu/research/chair-holder-olivier-humbert

5. Our Start-Up

- ExAdEx Innov https://exadex-innov.com/

 

EVENTS

Replays de la Winter School 2024

46th Conference of the Society of Neuroendocrinology

RECENT PUBLICATIONS

Batrow, P.-L., Roux, C.H., Gautier, N., Martin, L., Sibille, B., Guillou, H., Postic, C., Langin, D., Mothe-Satney, I., Amri, E.-Z., 2025. Regulation of UCP1 expression by PPARα and pemafibrate in human beige adipocytes. Life Sci 363, 123406. https://doi.org/10.1016/j.lfs.2025.123406

Joppin, V., Jourdan, A., Bendahan, D., Soucasse, A., Guye, M., Masson, C., Bège, T., 2025. Towards a better understanding of abdominal wall biomechanics: In vivo relationship between dynamic intra-abdominal pressure and magnetic resonance imaging measurements. Clin Biomech (Bristol) 121, 106396. https://doi.org/10.1016/j.clinbiomech.2024.106396

Rousseau, D., Bonnafous, S., Soysouvanh, F., Sarrail, D., Bourinet, M., Strazzulla, A., Patouraux, S., Borderie, A., Dolfi, B., Gallerand, A., Farrugia, M.A., Orian-Rousseau, V., Xu, Y., Williams, J.W., Ivanov, S., Tran, A., Anty, R., Luci, C., Gual, P., 2025. CD44 in myEloid cells is a major driver of liver inflammation and injury in alcohol-related liver disease. Hepatology. https://doi.org/10.1097/HEP.0000000000001232

Bège, T., Lasbleiz, A., Boullu, S., Gaborit, B., Berdah, S.V., Dutour, A., Duconseil, P., 2024. Two-Year Results of Sleeve Gastrectomy Combined with Posterior Fundoplication for Obesity Patients with Gastroesophageal Reflux Disease. Obes Surg 34, 2508–2514. https://doi.org/10.1007/s11695-024-07299-x

Díaz Del Moral, S., Wagner, N., Wagner, K.-D., 2024. The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair. Cells 13, 2078. https://doi.org/10.3390/cells13242078

Gallerand, A., Caillot, Z., Terekhova, M., Castiglione, A., Leporati, L., Giacchero, M., Pilot, T., Chang, M., Dolfi, B., Zair, F.N., Goës, E., Bennetot, A., Mlamla, Z., Mass, E., Ginhoux, F., Voehringer, D., Mack, M., Dombrowicz, D., Williams, J.W., Masson, D., Artyomov, M.N., Bertola, A., Ivanov, S., 2024a. CD226 + adipose tissue macrophages arise from MDP-derived monocytes and regulate lipid metabolism. bioRxiv 2024.12.03.626330. https://doi.org/10.1101/2024.12.03.626330

Gallerand, A., Dolfi, B., Stunault, M.I., Caillot, Z., Castiglione, A., Strazzulla, A., Chen, C., Heo, G.S., Luehmann, H., Batoul, F., Vaillant, N., Dumont, A., Pilot, T., Merlin, J., Zair, F.N., Gilleron, J., Bertola, A., Carmeliet, P., Williams, J.W., Arguello, R.J., Masson, D., Dombrowicz, D., Yvan-Charvet, L., Doyen, D., Haschemi, A., Liu, Y., Guinamard, R.R., Ivanov, S., 2024b. Glucose metabolism controls monocyte homeostasis and migration but has no impact on atherosclerosis development in mice. Nat Commun 15, 9027. https://doi.org/10.1038/s41467-024-53267-5

Gilleron, J., Chafik, A., Lacas-Gervais, S., Tanti, J.-F., Cormont, M., 2024. Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b. Cell Mol Biol Lett 29, 54. https://doi.org/10.1186/s11658-024-00574-w

Iltis, C., Moskalevska, I., Debiesse, A., Seguin, L., Fissoun, C., Cervera, L., Moudombi, L., Ardin, M., Ferrari, A., Eliott, C., Pisani, D., Ottaviani, A., Bourinet, M., Luci, C., Gual, P., Makulyte, G., Bernard, D., Durandy, M., Duret, L.C., Hamidouche, T., Kunz, S., Croce, O., Delannoy, C., Guérardel, Y., Allain, F., Hofman, P., Benarroch-Popivker, D., Bianchini, L., Dadone-Montaudie, B., Cosson, E., Guglielmi, J., Pourcher, T., Braud, V.M., Shkreli, M., Pers, Y.-M., Jorgensen, C., Brondello, J.-M., Féral, C.C., Michallet, M.-C., Gilson, E., Cherfils-Vicini, J., 2024. A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging. Nat Aging 1–18. https://doi.org/10.1038/s43587-024-00776-z

Lalis, M., Hladiš, M., Abi Khalil, S., Deroo, C., Marin, C., Bensafi, M., Baldovini, N., Briand, L., Fiorucci, S., Topin, J., 2024. A status report on human odorant receptors and their allocated agonists. Chem Senses 49, bjae037. https://doi.org/10.1093/chemse/bjae037

Le Corvec, M., Farrugia, M.A., Nguyen-Khac, E., Régimbeau, J.-M., Dharhri, A., Chatelain, D., Khamphommala, L., Gautier, A.-L., Le Berre, N., Frey, S., Bronowicki, J.-P., Brunaud, L., Maréchal, C., Blanchet, M.-C., Frering, V., Delwaide, J., Kohnen, L., Haumann, A., Delvenne, P., Sarfati-Lebreton, M., Tariel, H., Bernard, J., Toullec, A., Boursier, J., Bedossa, P., Gual, P., Anty, R., Iannelli, A., 2024. Blood-based MASH diagnostic in candidates for bariatric surgery using mid-infrared spectroscopy: a European multicenter prospective study. Sci Rep 14, 26452. https://doi.org/10.1038/s41598-024-72704-5

Pisani, D.F., Lettieri-Barbato, D., Ivanov, S., 2024. Polyamine metabolism in macrophage-adipose tissue function and homeostasis. Trends Endocrinol Metab 35, 937–950. https://doi.org/10.1016/j.tem.2024.05.008

Amri, E.-Z., 2024. Beige or brite adipocytes of the adipose organ: Link with white and brown adipocytes. Ann Endocrinol (Paris) 85, 253–254. https://doi.org/10.1016/j.ando.2024.05.002

Benamran, D., Chierici, A., Temime, V., Drai, C., Iannelli, A., 2024. Results of sleeve gastrectomy conversion to Roux-en-Y gastric bypass on gastroesophageal reflux disease symptoms and proton pump inhibitors use evolution over time. J Gastrointest Surg S1091-255X(24)00494–3. https://doi.org/10.1016/j.gassur.2024.06.001

Caci H, Chierici A, Iannelli A. Attention-deficit/hyperactivity disorder in adolescent and adult candidates for metabolic and bariatric surgery: A systematic review and meta-analysis. Obesity Reviews. 2024;e13802. doi:10.1111/obr.13802

Sanchez, C., Colson, C., Gautier, N., Noser, P., Salvi, J., Villet, M., Fleuriot, L., Peltier, C., Schlich, P., Brau, F., Sharif, A., Altintas, A., Amri, E.-Z., Nahon, J.-L., Blondeau, N., Benani, A., Barrès, R., Rovère, C., 2024. Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. Brain, Behavior, and Immunity 117, 330–346. https://doi.org/10.1016/j.bbi.2024.01.216

Temime, V., Ghanem, O.M., Heimbach, J.K., Diwan, T.S., Tranchart, H., Abdallah, H., Blanchard, C., Lontrichard, M., Reche, F., Borel, A.-L., Belluzzi, A., Foletto, M., Manno, E., Poghosyan, T., Chierici, A., Iannelli, A., 2024. Outcomes of bariatric surgery in the setting of compensated advanced chronic liver disease associated with clinically significant portal hypertension: a multicenter, retrospective, cohort study on feasibility and safety. Int J Surg 110, 3562–3570. https://doi.org/10.1097/JS9.0000000000001310

Díaz Del Moral, S., Benaouicha, M., Villa Del Campo, C., Torres, M., Wagner, N., Wagner, K.-D., Muñoz-Chápuli, R., Carmona, R., 2023. Cardiomyocyte-Specific Wt1 Is Involved in Cardiac Metabolism and Response to Damage. J Cardiovasc Dev Dis 10, 211. https://doi.org/10.3390/jcdd10050211

Bertola, A., Gallerand, A., Ivanov, S., 2022. Immune cell involvement in brown adipose tissue functions. Discov Immunol 1, kyac007. https://doi.org/10.1093/discim/kyac007

FOCUS OF THE MONTH

A huge shoutout to our very own ExAdEx-Innov startup, led by Drs Vincent Dani and Luigi Formicola, for receiving the Descroix-Vernier Ethicscience Jury Award – "Hope for Research" at the French Sénat on the 28th of March 2025!

Their groundbreaking project, ObFAT-3D, is revolutionizing metabolic research by developing ex vivo 3D human adipose tissues from patients undergoing metabolic and bariatric surgery.
These in vitro models accurately replicate the physiopathological responses of human tissues, paving the way for a deeper understanding of metabolic diseases and enabling preclinical testing, without the use of animal models.

Every other year, the Descroix-Vernier Awards recognize cutting-edge scientific programs that promote animal-free research through the latest advancements in science and technology.

Kudos to the entire ExAdEx-Innov team for their incredible work in pushing the boundaries of ethical and innovative research!

CONTACT

Dr Vanessa Lanoue BSc, MSc, PhD

Project officer for the Adipo-Cible consortium
Email vanessa.lanoue@univ-cotedazur.fr
https://www.linkedin.com/company/adipo-cible