Microbiologie Orale, Immunothérapie et Santé (MICORALIS)

Address :: Campus Saint Jean d’Angely-SJ2, Faculté de Chirurgie Dentaire 5, rue du 22ème BCA
06300 Nice
Phone :: 04 89 15 22 67
Email :: micoralis@univ-cotedazur.fr
On the Internet :: https://odontologie.univ-cotedazur.fr/recherche
Additional contact details :

General information

Affiliated institutions :

Université Côte d'Azur

Reference : UPR7354

Departments : DS 5 : Biologie Médecine et Santé

Organization

Director(s) :

Marlene Chevalier (Directeur adjoint)
Alain Doglio (Directeur)

Staff

Transdisciplinary research team (Dentists, Doctors, Pharmacists and Scientists)
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Dr. Alain DOGLIO has been Director of the MICORALIS Laboratory since its creation in 2015. He has also been in charge of the Cell Therapy Unit of the Nice University Hospital Center since 2007. Mail: alain.doglio@univ-cotedazur.fr

Dr Marlène Chevalier joined the team in 2009 and was appointed Deputy Director of the MICORALIS laboratory in September 2019. Mail: marlene.chevalier@univ-cotedazur.fr

Administrative contact : Julie Barbey 04 89 15 22 67

Activities

Research topics

Research themes centered on innovative topics:

PubMed

Microbiology and oral pathology. The visibility of the team, historically associated with the in vitro manipulation of multispecies oral biofilms, has been strengthened by the development of in vivo studies that have provided new data concerning the involvement of human herpesviruses as etiological agents in oral pathogenesis. Our recent work notably strengthens the international literature attributing a pathophysiological role to Epstein-Barr virus (EBV) in oral inflammatory lesions.

The OraCell platform. Globally called “OraCell Platform”, this project, supported by SATT Sud-Est, allows MICORALIS access to 2 primary cell culture models representative of 2 essential periodontal tissues: the alveolodental ligament (LAD ) and the junctional epithelium (JE). Added to the team's significant know-how in the field of handling multispecies oral biofilms, the availability of these models provides MICORALIS with significant added value in the world of oral research.

Use of lasers in dentistry. The anti-infective and anti-inflammatory properties of lasers open up a diverse field of therapeutic applications in dentistry. In particular, we have demonstrated the effectiveness of these lasers for the destruction of multispecies biofilms developing in the endocanal network of the tooth. This work is ongoing and relates in particular to the study of the immuno / microbiological responses of biofilms and oral cells exposed to low frequency lasers.

Détection par hybridation in situ, du virus Epstein Barr dans la parodontite Détection par hybridation in situ du virus Epstein Barr dans la parodontite.

Detection by in situ hybridization of Epstein Barr virus in periodontitis Detection by in situ hybridization of Epstein Barr virus in periodontitis.

biofilm Electron microscopy visualization of an oral biofilm reconstituted on dentin support

Languages spoken

French, English, Russian

Publications

Equipments

Microscopy
Cytometry
Cell culture
Bacteriology
Molecular biology
Histology and Immunochemistry

Partnerships

International relations

Since 2016, Jean-Paul Rocca, Université Côte d'Azur Emeritus Professor, member of MICORALIS, has been involved in the structuring of a large-scale partnership between Université Côte d'Azur / Faculty of Odontology, MICORALIS and the Hebei Medical University Hospital of Stomatology of Shijiazhuang (China) (framework agreement - MOU). In this context, collaboration with Chinese researchers is being established through joint publications and planned researcher and student exchanges.
Partnerships with the University of SaoPaulo, Brazil (Faculty of Dentistry). In collaboration with Dr. Braz-de Silva we are pursuing a scientific collaboration in the field of oral virology and associated pathologies. The projects in development involve large cohorts of Brazilian patients whose biological samples are analyzed in Brazil and at MICORALIS according to the specific areas of expertise of each partner.
Scientific collaboration with the University of Glasgow. in collaboration with Prof. Gordon Ramage and his team (Infection and Immunity Research Group, Glasgow Dental School) we studied the molecular mechanisms involved in fungal biofilms

Industrial relations

Our laboratory is invested in promoting its research work, in particular thanks to the historic partnership with the company Solidages. Solidages is a spin-off of Université Côte d'Azur, resulting from the academic work carried out by Prof. Isabelle Prêcheur, and Dr. Marlène Chevalier within the Oral Health and Aging Laboratory (LSBV) and now MICORALIS. The Solidages company develops oral health products, some of which are already on the market, such as “Protibis” biscuits, or close to being marketed (Buccovia, a product with oral anti-fungal activity). This company operates patent licenses filed within the framework of promoting research work carried out within LSBV, now MICORALIS. Other partnerships have been developed (Bonyf company).
Thanks to the support of SATT Sud-Est, the laboratory has set up a technology platform offering manufacturers suitable and relevant models for dental studies (OraCell platform).