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Abstract du Pr William A. Catterall, Department of Pharmacology, University of Washington Seattle USA, en visite à l'IPMC Sophia Antipolis
Electrical Signaling at Atomic Resolution
Electrical signals initiated by voltage-gated sodium and calcium channels initiate rapid physiological events from bacteria to man. Through structural studies of a bacterial ancestor of eukaryotic sodium and calcium channels, we have elucidated the structural basis for voltage-dependent activation and inactivation of these ion channels, their mechanism of ion conductance and selectivity, and the sites and mechanisms of action of channel-blocking drugs that are widely used in therapy of human diseases.
Electrical signals initiated by voltage-gated sodium and calcium channels initiate rapid physiological events from bacteria to man. Through structural studies of a bacterial ancestor of eukaryotic sodium and calcium channels, we have elucidated the structural basis for voltage-dependent activation and inactivation of these ion channels, their mechanism of ion conductance and selectivity, and the sites and mechanisms of action of channel-blocking drugs that are widely used in therapy of human diseases.
Dates
Créé le 8 février 2021